Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp306 | Muscle, physical activity and bone | ECTS2013

Increased activity associated with exercise does not rescue aged bone's impaired response to local mechanical loading

Meakin Lee , Udeh Chinedu , Sugiyama Toshihiro , Galea Gabriel , Lanyon Lance , Price Joanna

Bones’ fracture resistance is achieved in vivo by adaptation to habitual loading. Aged bone can adapt to exercise1 but in female rodents ageing impairs the adaptive response to artificial loading2,3. This inconsistency led us to investigate whether treadmill exercise, sufficiently mild to not itself stimulate new bone formation, could rescue aged bone’s diminished response to artificial loading.Young adult 17-week...